A wooden convent and church was built 1497-1504, by Franciscans from Sant'Agnese, on recently-reclaimed ground given by the republic. A miracle-working icon lead to the church being named Santa Maria dell'Assunta. Rebuilding, at the behest of Alvise Malipiero, probably by Tullio Lombardo, began in 1503 with the convent habitable by 1505, and the church open by 1523. The design of the church was said to have been based on that of its namesake in Rome. Malipiero's patronage continued until his death in 1557 and his burial in the family tomb here.